The Researcher’s Summary:
Systemic idiopathic juvenile arthritis (SJIA) is a chronic childhood disease that causes arthritis, fever, rash and other kinds of inflammation (e.g., around the heart and lungs). It is unknown what causes this disease, or what drives one of its main complications, called macrophage activation syndrome.
Notably, some patients respond to medication that inhibits IL-1, an inflammatory mediator made by the body. In conjunction with a trial of the IL-1 inhibitor rilanocept, we propose to investigate how IL-1 affects a particular immune cell type: the monocyte, which appears to be a key cell in SJIA pathology. We also hope to identify changes in monocytes during disease that predict response to rilanocept.